Scientific Publications

  • Automated Separation of Crude Extracts from Natural Products into Fractions for Primary High Throughput Screening
    David R. Appleton, Mark S. Butler, and Antony D. Buss
    Gilson Prefractionation App Note 2012


  • Identification of aluminium dioxalate in fungal cultures grown on vermiculite
    Mark S Butler, Kanagasundaram Yoganathan, Antony D Buss and Siewbee Ng
    The Journal of Antibiotics , (14 March 2012) | doi:10.1038/ja.2012.15


  • Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose
    Florian M.E. Wagenlehner, Christine M. Wagenlehner, Birgit Blenk, Holger Blenk, Sabine Schubert, Axel Dalhoff and Kurt G. Naber
    Chemotherapy 2011;57:97–107 DOI: 10.1159/000321028


  • In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
    Will Stubbings,Pamela Leow, Goh Chee Yong, Falicia Goh, Barbara Körber-Irrgang, Michael Kresken, Rainer Endermann, and Harald Labischinski
    Antimicrobial Agents And Chemotherapy, Sept. 2011, p. 4394–4397


  • Human Pharmacokinetics and Safety Profile of Finafloxacin, a New Fluoroquinolone Antibiotic, in Healthy Volunteers
    Heena Patel, Arne Andresen, Andreas Vente, Hans-Dietrich Heilmann, Will Stubbings, Michael Seiberling, Luis Lopez-Lazaro, Rolf Pokorny, and Harald Labischinski
    Antimicrobial Agents and Chemotherapy, September 2011,p. 4386-4393, Vol. 55, No. 9


  • Comparative in vitro activity of finafloxacin against staphylococci displaying normal and small colony variant phenotypes
    Evgeny A. Idelevich, Andre´ Kriegeskorte, William Stubbings, Barbara C. Kahl, Georg Peters and Karsten Becker
    J. Antimicrob. Chemother. (2011) doi: 10.1093/jac/dkr393 First published online: September 21, 2011


  • Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila
    Sandrine Lemaire, Francoise Van Bambeke, Paul M. Tulkens∗
    International Journal of Antimicrobial Agents 38 (2011) 52–59


  • Identification of a Naturally Occurring Quinazoline-4(3H)-one Firefly Luciferase Inhibitor
    Brinda Somanadhan, Chungyan Leong, Stephen R. Whitton, Siewbee Ng,  Antony D. Buss, Mark S. Butler 
    Journal of Natural Products, 2011, 74, 1500-1502


  • Comparative In Vitro Activities of the Novel Antibacterial Finafloxacin against selected Gram-Positive and Gram-Negative Bacteria Tested in Mueller-Hinton Broth and Synthetic Urine
    Axel Dalhoff, Will Stubbings and Sabine Schubert
    Antimicrobial Agents and Chemotherapy, 2011, 55, 1814-1818


  • Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates
    Paul G. Higgins, Will Stubbings, Hilmar Wisplinghoff and Harald Seifert
    Antimicrobial Agents and Chemotherapy, 2010, 54, 1613-1615


  • Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose
    Florian M. E. Wagenlehner, Christine M. Wagenlehner, Birgit Blenk, Holger Blenk, Sabine Schubert, Axel Dalhoff and Kurt G. Naber
    Chemotherapy, 2011, 57, 97-107


  • Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance
    Nadine-C. Emrich, Anke Heisig, Will Stubbings, Harald Labischinski and Peter Heisig
    J Antimicrob Chemother 2010; 65: 2530–2533


  • A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents
    Tuan Minh Nguyen, Nguyen Quang Vu, Jean-Jacques Youte, Jacelyn Lau, Angie Cheong,
    Ying San Ho, Benjamin S.W. Tan, Kanagasundaram Yoganathan, Mark S. Butler,
    Christina L.L. Chai*
    Tetrahedron 66 (2010) 9270-9276


  • Natural Product Chemistry for Drug Discovery,
    A.D. Buss and M.S. Butler Eds,
    in the RSC Biomolecular Sciences Series, the Royal Society of Chemistry, 2009


  • "A Benzopyrroloisoquinoline Alkaloid from Ficus fistulosa",
     G. Subramaniam, Kenny K. H. Ang, Siewbee Ng, Antony D. Buss and Mark S. Butler,
    Phytochemistry Letters, 2009, 2, 88-90


  • "The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate", 
    T. Schneider, K. Gries, M. Josten, I. Wiedemann, S. Pelzer, H. Labischinski and H.-G. Sahl,
    Antimicrobial Agents and Chemotherapy, 2009, 53,1610-1618


  • "Daptomycin versus Friulimicin B: in-depth profiling of Bacillus subtilis cell envelope stress responses",
    Tina Wecke, Daniela Zühlke, Ulrike Mäder, Sina Jordan, Birgit Voigt, Stefan Pelzer, Harald Labischinski, Georg Homuth, Michael Hecker and Thorsten Mascher,
    Antimicrobial Agents and Chemotherapy, 2009, 53, 1619-1623


  • "Prospects and challenges in Anti-infective research and development: new drugs and approaches.",
    Harald Labischinski and Helga Ruebsamen-Waigmann,
    Current Opinion in Pharmacology 2008, 8, 519-521


  • "Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl",
    Christian O. Janssen, Stephanie Lim, Ee Peng Lo, Kah Fei Wan, Victor C. Yu, May Ann Lee, Siew Bee Ng, Martin J. Everett, Antony D. Buss, David P. Lane and Rustum S. Boyce,
    Bioorganic and Medicinal Chemistry Letters 2008, 18, 5771-5773.


  • "Microsphaerins A–D, four novel benzophenone dimers with activity against MRSA from the fungus Microsphaeropsis sp.",
    K. Yoganathan, Shugeng Cao, Sharon C. Crasta, Srinivasulu Aitipamula, Stephen R. Whitton, Siewbee Ng, Antony D. Buss, Mark S. Butler,
    Tetrahedron 2008, 64, 10181-10187.


  • "Therapeutic compounds in nature as leads for new pharmaceuticals",
    A.D. Buss, B. Cox and R.D. Waigh, in Pharmacology; From Drug Development to Gene Therapy, Volume 1, Ed. R. A. Meyers,
    Wiley-VCH Verlag GmbH & Co., 2008, 359-417.


  • "Natural products to drugs: natural product-derived compounds in clinical trials”,
    Mark S, Butler,
    Natural Product Reports 2008, 25, 475-516.


  • “Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery”,
    Mark S. Butler and David J. Newman,
    Progress in Drug Research 2008, 65, 3-44.


  • “Inhibitors of bacterial virulence identified in a surrogate host model”,
    Mohammed Benghezal, Eric Adam, Aurore Lucas, Christine Burn, Michael G. Orchard, Christine Deuschel, Emilio Valentino, Stéphanie Braillard, Jean-Pierre Paccaud, Pierre Cosson,
    Cellular Microbiology, 2007, 9,, 1336-1342.


  • “The future of natural products as a source of new antibiotics”,
    Andriy Luzhetskyy, Stefan Pelzer and Andreas Bechthold,
    Current Opinion in Investigational Drugs 2007, 8, 608-613.


  • “A Simple Method for High Throughput Extract Prefractionation for Biological Screening”,
    David R. Appleton, Antony D. Buss and Mark S. Butler,
    Chimia 2007, 61, 327-331.


  • “A Genomic Screening Approach to the Structure-Guided Identification of Drug Candidates from Natural Sources” ,
    Andreas Hornung, Marcelo Bertazzo, Agnieszka Dziarnowski, Kathrin Schneider, Katrin Welzel, Sven-Eric Wohlert, Meike Holzenkämpfer, Graeme J. Nicholson, Andreas Bechthold, Roderich D. Süssmuth, Andreas Vente, and Stefan Pelzer,
    ChemBioChem 2007, 8, 757-766.


  • “Cloning and Heterologous Biosynthetic Gene Cluster Revealed a New Flexible Glycosyltransferase”,
    Andriy Luzhetskyy, Almuth Mayer,Jens Hoffmann, Stefan Pelzer, Meike Holzenk mper, Bettina Schmitt,Sven-Eric Wohlert,
    Andreas Vente and Andreas Bechthold ChemBioChem 2007, 8, 599-602.


  • “Sundaicumone A and B, Two Polyprenylated Acylphloroglucinol Derivatives from Calophyllum sundaicum with Weak Activity against the Glucocorticoid Receptor”,
    Shugeng Cao, Kia-Ngee Low, Robert P. Glover, Sharon C. Crasta, Siewbee Ng, Antony D. Buss and Mark S. Butler,
    Journal of Natural Products 2006, 69, 707-709.


  • “Natural Products – the Future Scaffolds for Novel Antibiotics?”,
    Mark S. Butler and Antony D. Buss,
    Biochemical Pharmacology 2006, 71, 919-929.


  • “Pyrrole Carboxamidine Tryptase Inhibitors from Leptonychia pubescens”,
    Lay Kien Yang, Sok Peng Ng, Horst Flotow, K. Yoganathan, B. O. Daramola, D. Doel Soejarto, Antony D. Buss and Mark S. Butler,
    Planta Medica 2005, 71, 1071-1072.


  • “NMR spectral assignments of three aspidofractinine alkaloids, kopsine, fruticosine and fruticosamine, isolated from Kopsia fruticosa”,
    Robert P. Glover, K. Yoganathan and Mark S. Butler,
    Magnetic Resonance in Chemistry 2005, 43, 483-486.


  • “Natural Products to Drugs: Natural Product Derived Compounds in Clinical Trials”,
    Mark S. Butler,
    Natural Product Reports 2005, 22, 162-195.


  • “New prenylflavone from Epimedium brevicornum is estrogenic but inhibits the growth of breast cancer cells”
    S. P. Yap, Y. H. Gong, P. Shen, Mark S. Butler, C. J. Loy and E. L. Yong,
    Planta Medica 2005, 71, 114-119.


  • “The Role of Natural Products in Drug Discovery”,
    Mark S. Butler,
    Journal of Natural Products 2004, 67, 2141-2153.


  • “A New Model for Utilising Chemical Diversity from Natural Sources”,
    Antony D. Buss and Mark S. Butler,
    Drug Development Research 2004, 62, 362-370.


  • “Isolation and Total Synthesis of Gymnastatin N, a Plk1 Active Constituent Isolated from the Fungus Arachniotus punctatus”,
    Chee Wee Phoon, Brinda Somanadhan, Sabrina Cher Hui Heng, Anna Ngo, Siew Bee Ng, Mark S. Butler, Antony D. Buss and Mui Mui Sim,
    Tetrahedron 2004, 60, 11619-11628.


  • “Inhibition of the Human Chemokine Receptor CCR5 by Variecolin and Variecolol and Isolation of Four New Variecolin Analogues, Emericolins A-D, from Emericella aurantiobrunnea”,
    K. Yoganathan, Christine Rossant, Robert P. Glover, Shugeng Cao, Jagadese J. Vittal, Siewbee Ng, Yicun Huang, Antony D. Buss and Mark S. Butler,
    Journal of Natural Products 2004, 67, 1681-1684
    .


  • “Cochlioquinones and Epi-cochlioquinones: Novel Antagonists of the Human Chemokine Receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum”,
    K. Yoganathan, Lay-Kien Yang, Christine Rossant, Yicun Huang, Siewbee Ng, Mark S. Butler and Antony D. Buss,
    Journal of Antibiotics 2004, 57, 59-63.


  • “Phenolic Derivatives from Wigandia urens with Weak Activity Against the Chemokine Receptor CCR5”,
    Shugeng Cao, Christine Rossant, Siewbee Ng, Antony D. Buss and Mark S. Butler,
    Phytochemistry, 2003, 64, 987-990
    .


  • “Ancisheynine, a Novel Naphthylisoquinolinium Alkaloid from Ancistrocladus heyneanus”,
    Lay-Kien Yang, Robert P. Glover, K. Yoganathan, Jayant P. Sarnaik, Archana J. Godbole, Doel D. Soejarto, Antony D. Buss and Mark S. Butler,
    Tetrahedron Letters 2003, 44, 5827-5829.


  • “Identification of Chelerythrine as an Inhibitor of BclXL Function”,
    Shing-Leng Chan, Mei Chin Lee, Kuan Onn Tan, Lay-Kien Yang, Alex S.Y. Lee, Horst Flotow, Nai Yang Fu, Mark S. Butler, Doel D. Soejarto, Antony D. Buss and Victor C. Yu,
    Journal of Biological Chemistry 2003, 278, 20453-20456.


  • “Flavonoids from Artocarpus lanceifolius Roxb.”,
    Shugeng Cao, Mark S. Butler and Antony D. Buss,
    Natural Product Research 2003, 17, 79-81.


  • “Development of a plasmepsin II fluorescence polarization assay suitable for high throughput anti-malarial drug discovery”,
    H. Flotow, C. Y. Leong, and A. D. Buss.
    Journal of Biomolecular Screening 2002, 7, 367-371.


  • “Three New Pyridoacridine Type Alkaloids from a Singaporean Ascidian”,
    Nilar, Philip J. Sidebottom, Brad K. Carté and Mark S. Butler.
    Journal of Natural Products 2002, 65, 1198-1200.


  • “Agonodepsides A and B: Two New Depsides from a Filamentous Fungus F7524”,
    Shugeng Cao, Alex S. Y. Lee, Yicun Huang, Horst Flotow, Siewbee Ng, Mark S. Butler and Antony D. Buss.
    Journal of Natural Products 2002, 65, 1037-1038.


  • "Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II”,
    Simon P. B. Ovenden, Shugeng Cao, Chungyan Leong, Horst Flotow, Marabir P. Gupta, Antony D. Buss and Mark S. Butler.
    Phytochemistry 2002, 60, 175-177.


  • “New Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic compounds from the Jamaican Sponge Smenospongia aurea”,
    Jin-Feng Hu, John A. Schetz, Michelle Kelly, Jiang-Nan Peng, Kenny K. H. Ang, Horst Flotow, Chung Yan Leong, Siew Bee Ng, Antony D. Buss, Scott P. Wilkins and Mark T. Hamann.
    Journal of Natural Products 2002, 65, 476-480.


  • “Benzylidene Rhodanines as Novel Inhibitors of UDP-N-Acetylmuramate: L-Alaine Ligase”,
    Mui Mui Sim, Siew Bee Ng, Antony David Buss, Sharon Carmelita Crasta, Kay Lin Goh and Sue Kim Lee.
    Bioorganic Medicinal Chemistry Letters 2002, 12, 697-699.


  • “Ardisiaquinones from Ardisia teysmanniana”,
    Lay-Kien Yang, Corinne Khoo-Beattie, Kay Lin Goh, Bee Lee Chng, K. Yoganathan, Yee Hing Lai and Mark S. Butler,
    Phytochemistry 2001, 58, 1235-1238.